Single-Cell Transcriptomics of Multiple Brain Regions in ME/CFS
Many symptoms of ME/CFS may be linked to changes in the immune system and the brain. In this project, researchers are using single-nucleus RNA sequencing, a technique that allows them to examine in detail which brain cells and immune cells function differently in people with ME/CFS. They will study several brain regions, including the hippocampus, frontal cortex, and hypothalamus, which are involved in energy regulation, memory, and hormones.
Aim and Approach
The aim is to better understand the changes that occur at the cellular level in ME/CFS. To investigate this, the researchers will use brain tissue from donors to the Netherlands Brain Bank. They will study gene activity and changes in brain cells and compare these with immune cells in the blood.
Expected Results
The results should provide a clearer understanding of how the immune system and the brain influence each other. This insight could help in developing new ways to diagnose and treat ME/CFS.
